| Pick | Team | Player | Pos. | School |
| Round 1 |
| 1 |
Browns
| Baker Mayfield | QB | Oklahoma |
| 2 |
Giants
| Saquon Barkley | RB | Penn State |
| 3 |
Jets
f/IND
| Sam Darnold | QB | Southern Cal |
| 4 |
Browns
f/HOU
| Bradley Chubb | DE | North Carolina State |
| 5 |
Broncos
| Quenton Nelson | OG | Notre Dame |
| 6 |
Colts
f/NYJ
| Denzel Ward | CB | Ohio State |
| 7 |
Buccaneers
| Roquan Smith | IB | Georgia |
| 8 |
Bears
| Tremaine Edmunds | OB | Virginia Tech |
| 9 |
49ers
| Vita Vea | DT | Washington |
| 10 |
Raiders
| Derwin James | SS | Florida State |
| 11 |
Dolphins
| Josh Rosen | QB | UCLA |
| 12 |
Bills
f/BUF
| Josh Allen | QB | Wyoming |
| 13 |
Commanders
| Taven Bryan | DT | Florida |
| 14 |
Packers
| Minkah Fitzpatrick | CB | Alabama |
| 15 |
Cardinals
| Harold Landry | OB | Boston College |
| 16 |
Ravens
| Mike McGlinchey | OT | Notre Dame |
| 17 |
Chargers
| Frank Ragnow | OC | Arkansas |
| 18 |
Seahawks
| Lamar Jackson | QB | Louisville |
| 19 |
Cowboys
| Da'Ron Payne | DT | Alabama |
| 20 |
Lions
| Marcus Davenport | DE | Texas-San Antonio |
| 21 |
Bengals
f/CIN
| Kolton Miller | OT | UCLA |
| 22 |
Bills
f/KC
| Calvin Ridley | WR | Alabama |
| 23 |
Patriots
f/LAR
| Mason Rudolph | QB | Oklahoma State |
| 24 |
Panthers
| Will Hernandez | OG | UTEP |
| 25 |
Titans
| Justin Reid | SS | Stanford |
| 26 |
Falcons
| Maurice Hurst | DT | Michigan |
| 27 |
Saints
| James Daniels | OC | Iowa |
| 28 |
Steelers
| Rashaan Evans | OB | Alabama |
| 29 |
Jaguars
| DJ Chark | WR | LSU |
| 30 |
Vikings
| Carlton Davis | CB | Auburn |
| 31 |
Patriots
| Dallas Goedert | TE | South Dakota State |
| 32 |
Eagles
| Tyrell Crosby | OT | Oregon |
| Round 2 |
| 33 |
Browns
| Brian O'Neill | OT | Pittsburgh |
| 34 |
Giants
| Isaiah Oliver | CB | Colorado |
| 35 |
Browns
f/HOU
| Ronnie Harrison | FS | Alabama |
| 36 |
Colts
| Derrius Guice | RB | LSU |
| 37 |
Colts
f/NYJ
| Sam Hubbard | DE | Ohio State |
| 38 |
Buccaneers
| Mike Hughes | CB | Central Florida |
| 39 |
Bears
| Jaire Alexander | CB | Louisville |
| 40 |
Broncos
| Lorenzo Carter | OB | Georgia |
| 41 |
Raiders
| Orlando Brown | OT | Oklahoma |
| 42 |
Dolphins
| Isaiah Wynn | OG | Georgia |
| 43 |
Patriots
f/SF
| Marcus Allen | FS | Penn State |
| 44 |
Commanders
| DJ Moore | WR | Maryland |
| 45 |
Packers
| Jamarco Jones | OT | Ohio State |
| 46 |
Bengals
| Rasheem Green | DT | Southern Cal |
| 47 |
Cardinals
| Leighton Vander Esch | OB | Boise State |
| 48 |
Chargers
| Harrison Phillips | DT | Stanford |
| 49 |
Colts
f/NYJ/SEA
| Connor Williams | OT | Texas |
| 50 |
Cowboys
| Mike Gesicki | TE | Penn State |
| 51 |
Lions
| Hayden Hurst | TE | South Carolina |
| 52 |
Ravens
| Tim Settle | DT | Virginia Tech |
| 53 |
Bills
| Jessie Bates III | SS | Wake Forest |
| TRADE - Denver's last pick from the trade with Buffalo and moving out of the 5 hole. |
| 54 |
Chiefs
| PJ Hall | DT | Sam Houston State |
| 55 |
Panthers
| Deon Cain | WR | Clemson |
| 56 |
Bills
f/LAR
| Donte Jackson | CB | LSU |
| 57 |
Titans
| Antonio Callaway | WR | Florida |
| 58 |
Falcons
| Kyzir White | SS | West Virginia |
| 59 |
49ers
f/NO
| Ronald Jones | RB | Southern Cal |
| 60 |
Steelers
| Derrick Nnadi | DT | Florida State |
| 61 |
Jaguars
| Christian Kirk | WR | Texas A&M |
| 62 |
Vikings
| Billy Price | OC | Ohio State |
| 64 |
Browns
f/PHI
| Dante Pettis | WR | Washington |
| Round 3 |
| 65 |
Bills
f/CLE
| Jalyn Holmes | DE | Ohio State |
| 66 |
Giants
| Darius Leonard | IB | South Carolina State |
| 67 |
Colts
| Nate Shepherd | DT | Fort Hays State |
| 68 |
Texans
| Duke Dawson | CB | Florida |
| 69 |
Buccaneers
| Sony Michel | RB | Georgia |
| 70 |
49ers
f/CHI
| Rashaad Penny | RB | San Diego State |
| 71 |
Broncos
| James Washington | WR | Oklahoma State |
| 72 |
Giants
f/TB
| Mike White | QB | Western Kentucky |
| 73 |
Dolphins
| Jerome Baker | OB | Ohio State |
| 74 |
49ers
| Fred Warner | OB | BYU |
| 75 |
Raiders
| Tegray Scales | IB | Indiana |
| 76 |
Packers
| Michael Gallup | WR | Colorado State |
| 77 |
Bengals
| Ian Thomas | TE | Indiana |
| 78 |
Chiefs
f/WAS
| Nick Nelson | CB | Wisconsin |
| 79 |
Cardinals
| Equanimeous St. Brown | WR | Notre Dame |
| 80 |
Texans
f/SEA
| BJ Hill | DT | North Carolina State |